Pavlo Hrab

(Marine) Bioinformatics Researcher | PhD Candidate

Bioinformatician studying microbial communities by combining molecular lab and computational multi-omics approaches. Currently focused on Acidobacteriota - a biosynthetically rich yet understudied bacterial phylum. I integrate metagenomics, metatranscriptomics, and cultivation to discover novel natural products and understand how bacteria adapt to their hosts.

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Pavlo Hrab
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Genomes Analyzed

Research Focus

(Marine) Microbiome Genomics

Investigating microbial communities in marine sponges using metagenomics and genomics to uncover hidden diversity, with focus on understudied bacterial phyla like Acidobacteriota

Natural Product Discovery

Mining novel biosynthetic gene clusters from undercharacterized bacterial lineages using unconventional computational approaches and large-scale genomic datasets

Comparative Genomics

Reconstructing evolutionary relationships and identifying genomic adaptations across bacterial lineages using phylogenomics and comparative analyses

Host-Microbe Interactions

Understanding what drives bacteria to associate with marine sponge hosts, distinguishing ecological adaptation from shared ancestry

Featured Projects

Current research projects and ongoing work

Global biosynthetic potential of Acidobacteriota

Ongoing

2023 - Present

We aim to comprehensively annotate the biosynthetic potential of phylum Acidobacteriota, using publicly available metagenomics datasets.

BGC miningMetagenomics
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Targeted bacteria isolation from deep-sea sponge Geodia barretti

Ongoing

2022 - Present

We aim to use bioinformatics functional prediction of target bacteria to shape the media composition used for isolation experiments

Bacteria cultivationMetagenomicsMetatranscriptomicsSequencing
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Host adaptations of marine Acidobacteriota

Ongoing

2024 - Present

We use publicly available data to define marine host-associated Acidobacteriota and investigate what drives their host-association (in context of marine sponges)

Machine learningMetagenomicsPhylogenomics
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Recent Publications

Selected recent research papers and conference proceedings.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Mitja M Zdouc, Kai Blin, .... Pavlo Hrab,... Tilmann Weber, Marnix H Medema

Nucleic Acids Research 53(D1):D678–D690, 2024

Complete genome sequence of Streptomyces cyanogenus S136, producer of anticancer angucycline landomycin A.

Hrab, P., Rückert, C., Busche, T., Ostash, I., Kalinowski, J., Fedorenko, V., Yushchuk, O., & Ostash, B.

3 Biotech, 11(6), 282, 2021

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Latest News

Recent updates, talks, and academic activities.

November 2025

Lauched a pesonal website!
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